Therapeutic Angiogenesis via Solar Cell-Facilitated Electrical Stimulation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Gun-Jae | - |
dc.contributor.author | Oh, Jin Young | - |
dc.contributor.author | Kim, Yeon-Ju | - |
dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Jang, Hyeon-Ki | - |
dc.contributor.author | Han, Jin | - |
dc.contributor.author | Yoon, Jeong-Kee | - |
dc.contributor.author | Kwon, Sang-Mo | - |
dc.contributor.author | Lee, Tae Ii | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.available | 2020-02-27T16:42:32Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-11-08 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5465 | - |
dc.description.abstract | Cell therapy has been suggested as a treatment modality for ischemic diseases, but the poor survival and engraftment of implanted cells limit its therapeutic efficacy. To overcome such limitation, we used electrical stimulation (ES) derived from a wearable solar cell for inducing angiogenesis in ischemic tissue. ES enhanced the secretion of angiogenic growth factors and the migration of mesenchymal stem cells (MSCs), myoblasts, endothelial progenitor cells, and endothelial cells in vitro. In a mouse ischemic hindlimb model, ES generated by a solar cell and applied to the ischemic region promoted migration of MSCs toward the ischemic site and upregulated expression of angiogenic paracrine factors (vascular endothelial, basic fibroblast, and hepatocyte growth factors; and stromal cell-derived factor-l alpha). Importantly, solar cell-generated ES promoted the formation of capillaries and arterioles at the ischemic region, attenuated muscle necrosis and fibrosis, and eventually prevented loss of the ischemic limb. Solar cell ES therapy showed higher angiogenic efficacy than conventional MSC therapy. This study shows the feasibility of using solar cell ES as a novel treatment for therapeutic angiogenesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.subject | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject | BONE-MARROW-CELLS | - |
dc.subject | FUNCTIONAL CONSEQUENCES | - |
dc.subject | IN-VIVO | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | MODEL | - |
dc.subject | RESPONSES | - |
dc.subject | FIELDS | - |
dc.title | Therapeutic Angiogenesis via Solar Cell-Facilitated Electrical Stimulation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000415140800021 | - |
dc.identifier.doi | 10.1021/acsami.7b13322 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.9, no.44, pp.38344 - 38355 | - |
dc.identifier.scopusid | 2-s2.0-85033593016 | - |
dc.citation.endPage | 38355 | - |
dc.citation.startPage | 38344 | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 44 | - |
dc.contributor.affiliatedAuthor | Lee, Tae Ii | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | electrical stimulation | - |
dc.subject.keywordAuthor | hindlimb ischemia | - |
dc.subject.keywordAuthor | solar cell | - |
dc.subject.keywordAuthor | cell homing | - |
dc.subject.keywordAuthor | paracrine factor secretion | - |
dc.subject.keywordPlus | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | BONE-MARROW-CELLS | - |
dc.subject.keywordPlus | FUNCTIONAL CONSEQUENCES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | FIELDS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.