Therapeutic Angiogenesis via Solar Cell-Facilitated Electrical Stimulation
- Authors
- Jeong, Gun-Jae; Oh, Jin Young; Kim, Yeon-Ju; Bhang, Suk Ho; Jang, Hyeon-Ki; Han, Jin; Yoon, Jeong-Kee; Kwon, Sang-Mo; Lee, Tae Ii; Kim, Byung-Soo
- Issue Date
- 8-Nov-2017
- Publisher
- AMER CHEMICAL SOC
- Keywords
- angiogenesis; electrical stimulation; hindlimb ischemia; solar cell; cell homing; paracrine factor secretion
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.9, no.44, pp.38344 - 38355
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 9
- Number
- 44
- Start Page
- 38344
- End Page
- 38355
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5465
- DOI
- 10.1021/acsami.7b13322
- ISSN
- 1944-8244
- Abstract
- Cell therapy has been suggested as a treatment modality for ischemic diseases, but the poor survival and engraftment of implanted cells limit its therapeutic efficacy. To overcome such limitation, we used electrical stimulation (ES) derived from a wearable solar cell for inducing angiogenesis in ischemic tissue. ES enhanced the secretion of angiogenic growth factors and the migration of mesenchymal stem cells (MSCs), myoblasts, endothelial progenitor cells, and endothelial cells in vitro. In a mouse ischemic hindlimb model, ES generated by a solar cell and applied to the ischemic region promoted migration of MSCs toward the ischemic site and upregulated expression of angiogenic paracrine factors (vascular endothelial, basic fibroblast, and hepatocyte growth factors; and stromal cell-derived factor-l alpha). Importantly, solar cell-generated ES promoted the formation of capillaries and arterioles at the ischemic region, attenuated muscle necrosis and fibrosis, and eventually prevented loss of the ischemic limb. Solar cell ES therapy showed higher angiogenic efficacy than conventional MSC therapy. This study shows the feasibility of using solar cell ES as a novel treatment for therapeutic angiogenesis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 공과대학 > 신소재공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5465)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.