Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases
- Authors
- Byun, Kyunghee; Yoo, YongCheol; Son, Myeongjoo; Lee, Jaesuk; Jeong, Goo-Bo; Park, Young Mok; Salekdeh, Ghasem Hosseini; Lee, Bonghee
- Issue Date
- Sep-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Advanced glycation end products (AGES); Receptor for AGES (RAGE); Macrophage; Inflammation; Degenerative diseases
- Citation
- PHARMACOLOGY & THERAPEUTICS, v.177, pp.44 - 55
- Journal Title
- PHARMACOLOGY & THERAPEUTICS
- Volume
- 177
- Start Page
- 44
- End Page
- 55
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5739
- DOI
- 10.1016/j.pharmthera.2017.02.030
- ISSN
- 0163-7258
- Abstract
- Advanced glycation end products (AGEs) and their receptor have been implicated in the progressions of many intractable diseases, such as diabetes and atherosclerosis, and are also critical for pathologic changes in chronic degenerative diseases, such as Alzheimer's disease, Parkinson's disease, and alcoholic brain damage. Recently activated macrophages were found to be a source of AGEs, and the most abundant form of AGEs, AGE-albumin excreted by macrophages has been implicated in these diseases and to act through common pathways. AGEs inhibition has been shown to prevent the pathogenesis of AGEs-related diseases in human, and therapeutic advances have resulted in several agents that prevent their adverse effects. Recently, anti-inflammatory molecules that inhibit AGEs have been shown to be good candidates for ameliorating diabetic complications as well as degenerative diseases. This review was undertaken to present, discuss, and clarify current understanding regarding AGEs formation in association with macrophages, different diseases, therapeutic and diagnostic strategy and links with RAGE inhibition. (C)2017 The Author(s). Published by Elsevier Inc.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5739)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.