Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities
DC Field | Value | Language |
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dc.contributor.author | Suh, Won Se | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-27T17:42:38Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5745 | - |
dc.description.abstract | Six new iridoid glycosides, sambucusides A-F (1-6), and two known derivatives (7 and 8) were isolated from a methanol extract of the twigs of Sambucus williamsii var. coreana. Their chemical structures were elucidated by spectroscopic methods, including NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HMQC, HMBC, and NOESY) and HRMS. All isolated compounds (1-8) were evaluated for their antiproliferative activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Their effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells and their neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells were also examined. Compounds 2, 3, and 5 showed cytotoxic effects (IC50 1.3-8.7 mu M) against the SK-MEL-2 and Bt549 cell lines and inhibitory effects on NO production (IC50 of 0.9, 1.3, and 1.2 mu M, respectively). Compounds 2, 4, and 8 exhibited NGF-releasing effects (147.0 +/- 5.8%, 158.7 +/- 5.2%, and 152.6 +/- 7.3%, respectively). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.subject | VIBURNUM-TINUS | - |
dc.subject | UMR106 CELLS | - |
dc.subject | GLUCOSIDES | - |
dc.subject | CONSTITUENTS | - |
dc.subject | LIGNANS | - |
dc.subject | HANCE | - |
dc.subject | CYTOTOXICITY | - |
dc.title | Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000411848300015 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.7b00410 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.80, no.9, pp.2502 - 2508 | - |
dc.identifier.scopusid | 2-s2.0-85029773017 | - |
dc.citation.endPage | 2508 | - |
dc.citation.startPage | 2502 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 80 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | VIBURNUM-TINUS | - |
dc.subject.keywordPlus | UMR106 CELLS | - |
dc.subject.keywordPlus | GLUCOSIDES | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | LIGNANS | - |
dc.subject.keywordPlus | HANCE | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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