Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities
- Authors
- Suh, Won Se; Kim, Chung Sub; Subedi, Lalita; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Sep-2017
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.80, no.9, pp.2502 - 2508
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 80
- Number
- 9
- Start Page
- 2502
- End Page
- 2508
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5745
- DOI
- 10.1021/acs.jnatprod.7b00410
- ISSN
- 0163-3864
- Abstract
- Six new iridoid glycosides, sambucusides A-F (1-6), and two known derivatives (7 and 8) were isolated from a methanol extract of the twigs of Sambucus williamsii var. coreana. Their chemical structures were elucidated by spectroscopic methods, including NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HMQC, HMBC, and NOESY) and HRMS. All isolated compounds (1-8) were evaluated for their antiproliferative activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Their effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells and their neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells were also examined. Compounds 2, 3, and 5 showed cytotoxic effects (IC50 1.3-8.7 mu M) against the SK-MEL-2 and Bt549 cell lines and inhibitory effects on NO production (IC50 of 0.9, 1.3, and 1.2 mu M, respectively). Compounds 2, 4, and 8 exhibited NGF-releasing effects (147.0 +/- 5.8%, 158.7 +/- 5.2%, and 152.6 +/- 7.3%, respectively).
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