Protective effect of lanostane triterpenoids from the sclerotia of Poria cocos Wolf against cisplatin-induced apoptosis in LLC-PK1 cells
- Authors
- Lee, Dahae; Lee, Seulah; Shim, Sang Hee; Lee, Hae-Jeung; Choi, Youkyung; Jang, Tae Su; Kim, Ki Hyun; Kang, Ki Sung
- Issue Date
- 1-Jul-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Poria cocos Wolf; Polyporaceae; Lanostane triterpenoids; Nephrotoxicity; Cisplatin
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.13, pp.2881 - 2885
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 13
- Start Page
- 2881
- End Page
- 2885
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5926
- DOI
- 10.1016/j.bmcl.2017.04.084
- ISSN
- 0960-894X
- Abstract
- Cisplatin-induced nephrotoxicity is a serious adverse effect that limits the use of cisplatin in cancer patients. In the present study, we investigated the protective effect of lanostane triterpenoids (1-10) isolated from the ethanolic extract of Poria cocos Wolf against cisplatin-induced cell death in LLC-PK1 kidney tubular epithelial cells. Treatment of cisplatin induced significant cell death, which was suppressed by treatment with dehydroeburicoic acid monoacetate (1) and 3b-acetoxylanosta-7,9(11), 24-trien-21-oic acid (9). Compound 1 exhibited the highest efficacy among the tested compounds and was thus subjected to further mechanistic studies. The increase in the percentage of apoptotic cells induced by cisplatin reduced by 4.3% after co-treatment of cells with compound 1 (50 and 100 mu M). Furthermore, phosphorylation of the mitogen-activated protein kinases JNK, ERK, and p38, and caspase-3, which characterize oxidative stress-mediated apoptosis, increased significantly after treatment with cisplatin, and decreased after treatment with compound 1. These results indicate that the renoprotective effects of compound 1 may be mediated by its anti-apoptotic activity. (C) 2017 Elsevier Ltd. All rights reserved.
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