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The role of hepatic stellate cells in fibrotic liver diseasesThe role of hepatic stellate cells in fibrotic liver diseases
- Other Titles
- The role of hepatic stellate cells in fibrotic liver diseases
- Issue Date
- Jun-2020
- Publisher
- 사단법인 한국동물생명공학회
- Keywords
- hepatic stellate cells; liver fibrosis; liver injury
- Citation
- 한국동물생명공학회지, v.35, no.2, pp.113 - 118
- Journal Title
- 한국동물생명공학회지
- Volume
- 35
- Number
- 2
- Start Page
- 113
- End Page
- 118
- ISSN
- 2671-4639
- Abstract
- Hepatic stellate cells (HSCs) play essential roles in normal and pathophysiological function in liver. In steady state, HSCs contribute to retinoid storage, immune tolerance, and extracellular matrix (ECM) homeostasis. Upon liver injury, they become activated and lead to morphological and functional changes. Studies have demonstrated that activation of HSCs by various stimuli such as toxins, microbial infection, or metabolic overload can promote the fibrotic changes in liver by production of ECM. Herein, we provide current knowledge about the basic characteristics of HSCs and the mechanism by which they are activated.
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