Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study
- Authors
- Jung J.; Choi Y.S.; Lee J.H.; Lee W.S.; Kim S.-H.; Park Y.; Lee S.-S.; Do Y.R.; Jo J.-C.; Lee J.-J.; Kim J.S.; Shin H.-J.; Shin D.-Y.; Yoon S.-S.; Min C.-K.; Kim K.; Eom H.-S.; The Korean Multiple Myeloma Working Party (KMMWP)
- Issue Date
- Jul-2020
- Publisher
- Springer
- Keywords
- Autologous; Elderly; Multiple myeloma; Stem cell; Transplantation
- Citation
- International Journal of Hematology
- Journal Title
- International Journal of Hematology
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/60118
- DOI
- 10.1007/s12185-020-02869-y
- ISSN
- 0925-5710
- Abstract
- Autologous stem cell transplantation (ASCT) is not frequently performed for elderly patients multiple myeloma (MM) in Korea, despite its being a standardized approach for young patients. Medical records of 150 patients from 15 Korean institutions who received ASCT at age ≥ 64 years were analyzed retrospectively. Patients included had symptomatic MM, and had received their first ASCT at age ≥ 64 following induction chemotherapy. The main outcome was the response after ASCT. Overall survival (OS) and progression-free survival (PFS) were also analyzed. Median time to ASCT was 6.3 months. Complete response plus stringent complete response rate increased from 36 (24.0%) to 105 (70.0%) after ASCT, and high-quality response (≥ very good partial response) increased from 96 (64.0%) to 125 (83.3%). With a median follow-up of 32.6 months after ASCT, 5-year OS and PFS were 59.7% and 22.8%, respectively. Febrile neutropenia occurred in 43.5%, and nausea (21.3%) and stomatitis (13.2%) were common grade 3–4 non-hematologic adverse events. Of 44 deaths, disease progression (n = 23) was the most common cause of mortality, followed by infection (n = 13). Treatment-related death occurred in four cases (2.7%). ASCT is an effective and safe option for elderly MM patients and is associated with superior clinical outcomes. © 2020, Japanese Society of Hematology.
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