Implications of infiltrating immune cells within bone marrow of patients with diffuse large B-cell lymphoma
- Authors
- Jeong, Juhyeon; Oh, Eun Ji; Yang, Woo Ick; Kim, Soo Jeong; Yoon, Sun Och
- Issue Date
- Jun-2017
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Keywords
- Diffuse large B-cell lymphoma; Bone marrow; CD8+T cells; Microenvironment; Prognosis
- Citation
- HUMAN PATHOLOGY, v.64, pp.222 - 231
- Journal Title
- HUMAN PATHOLOGY
- Volume
- 64
- Start Page
- 222
- End Page
- 231
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6091
- DOI
- 10.1016/j.humpath.2017.04.012
- ISSN
- 0046-8177
- Abstract
- The implications of infiltrating immune cells, especially T cells and macrophages, in the bone marrow (BM) microenvironment of patients with diffuse large B-cell lymphoma (DLBCL) have rarely been studied. We aimed to investigate the significance of infiltrating immune cells in the BM microenvironment as a prognostic factor for DLBCL patients. Using the initial pretreatment BM biopsy obtained from 198 DLBCL patients, we semiquantitatively evaluated CD3+ T cells, CD8+ T cells, and CD163+ macrophages that infiltrate into the paratrabecular and interstitial areas of BM by immunohistochemistry and analyzed their clinicopathological and prognostic implications. Levels of infiltrating CD3+ T cells, CD8+ T cells, and CD163+ macrophages were significantly higher in BM with DLBCL involvement (BMI-positive group) than in that without DLBCL involvement (BMI-negative group). Infiltration of CD8+ T cells significantly increased in cases with advanced Ann Arbor stage, elevated lactate dehydrogenase level, extranodal site involvement >= 2 sites, higher Eastern Cooperative Oncology Group performance status, and higher International Prognostic Index (IPI) risk. High levels of CD3+ T cells were significantly associated with age <= 60, and high levels of CD163+ macrophages were associated with advanced Ann Arbor stage and higher IPI risk. High infiltration of CD8+ T cells was significantly related to inferior overall and recurrence-free survival rate, even in the BMI-negative group. High infiltration of CD8+ T cells within the pretreatment BM was related to poor prognosis, and might be a useful prognostic factor of DLBCL patients. Therefore, evaluation of CD8+ T cells is helpful for predicting prognosis in initial pretreatment BM biopsy of DLBCL patients. (C) 2017 Elsevier Inc. All rights reserved.
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