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A biphenyl derivative from the twigs of Chaenomeles speciosa
- Authors
- Suh, Won Se; Park, Kyoung Jin; Kim, Dong Hyun; Subedi, Lalita; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Jun-2017
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Chaenomeles speciosa; Biphenyl; Cytotoxicity; Anti-neuroinflammatory
- Citation
- BIOORGANIC CHEMISTRY, v.72, pp.156 - 160
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 72
- Start Page
- 156
- End Page
- 160
- ISSN
- 0045-2068
- Abstract
- In our continuing search for bioactive constituents of Korean medicinal sources, we investigated an 80% MeOH extract of the twigs of Chaenomeles speciosa. Column chromatographic purification of the CHCl3 fraction resulted in the isolation of a new biphenyl derivative (1), along with four known biphenyl compounds (2-5) and six triterpenes (6-11). The chemical structure of the new compound was determined on the basis of spectroscopic analyses including 1D and 2D NMR data. Among isolates, compound 3 exhibited potent cytotoxic activities against SK-OV-3, SK-MEL-2, and XF498 cell lines (IC50 = 5.91, 4.22, and 6.28 mu M, respectively). Also, Compounds 9 and 10 showed strong anti-neuroinflammatory activities (IC50 2.38, and 6.70 mu M, respectively). (C) 2017 Elsevier Inc. All rights reserved.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)