Low-noise wide-bandwidth DNA readout instrument for nanopore applications
- Authors
- Yun, J.; Choi, H.; Kim, J.
- Issue Date
- 25-May-2017
- Publisher
- INST ENGINEERING TECHNOLOGY-IET
- Citation
- ELECTRONICS LETTERS, v.53, no.11, pp.707 - 708
- Journal Title
- ELECTRONICS LETTERS
- Volume
- 53
- Number
- 11
- Start Page
- 707
- End Page
- 708
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6115
- DOI
- 10.1049/el.2017.0870
- ISSN
- 0013-5194
- Abstract
- A low-noise, wide-bandwidth DNA readout instrument for nanopore applications is presented. Owing to hardware simplicity and reliability, a resistive-feedback transimpedance amplifier (rf-TIA) is adopted as the headstage for the readout instrument. However, to achieve a high gain and low input noise, its high feedback resistance induces a high parasitic capacitance, thus significantly limiting the 3 dB bandwidth. To drastically reduce the parasitic capacitance and widen the bandwidth, a novel rf-TIA architecture is fabricated that utilises a split-resistor technique for the high feedback resistor. This is demonstrated in a benchtop test employing an a-haemolysin nanopore.
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