A synthetic Nitraria alkaloid, isonitramine protects pancreatic beta-cell and attenuates postprandial hyperglycemia
DC Field | Value | Language |
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dc.contributor.author | Kwon, So Jung | - |
dc.contributor.author | Hwang, Su Jung | - |
dc.contributor.author | Jung, Yeonghun | - |
dc.contributor.author | Park, Hyeung-geun | - |
dc.contributor.author | Kim, Mi-hyun | - |
dc.contributor.author | Park, Yohan | - |
dc.contributor.author | Lee, Hyo-Jong | - |
dc.date.available | 2020-02-27T18:43:44Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6144 | - |
dc.description.abstract | Objective. The extracts of Nitraria genus are composed of Nitraria alkaloids and have been used traditionally as a hypoglycemic medicine. However, the efficacy and precise mechanism of Nitraria alkaloids remain largely unknown. Methods. Previously, we reported the total synthesis of (+)-isonitramine, one of Nitraria alkaloids. In this study, we investigated the and-diabetic potential of isonitramine in diabetes mellitus and its underlying molecular mechanism in carbohydrate catabolism in vitro and in vivo. Results. Isonitramine exerted significant inhibitory effect on alpha-glucosidases but not alpha-amylase in vitro. In zebrafish, isonitramine alleviated the streptozotocin (SIZ)-induced postprandial hyperglycemia and protected the pancreatic damages against alloxan-induced oxidative stress in vivo. Also, isonitramine induced insulin without any toxicities and downregulated phosphoenolpyruvate caxboxykinase (PEPCK), which catalyzes the first committed step in gluconeogenesis. Conclusion. Taken together, isonitramine inhibited a-glucosidase activity and PEPCK expression, while increased insulin expression, resulting in attenuating the postprandial hyperglycemia. Also, isonitramine protected the pancreas from ROS-mediated toxicities. Therefore, isonitramine may be a new drug candidate for the treatment of diabetes mellitus. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.subject | PHOSPHOENOLPYRUVATE CARBOXYKINASE | - |
dc.subject | ALPHA-GLUCOSIDASE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | LEAF EXTRACTS | - |
dc.subject | MODEL | - |
dc.subject | ZEBRAFISH | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | INHIBITION | - |
dc.subject | EXPRESSION | - |
dc.subject | MECHANISM | - |
dc.title | A synthetic Nitraria alkaloid, isonitramine protects pancreatic beta-cell and attenuates postprandial hyperglycemia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000400037600011 | - |
dc.identifier.doi | 10.1016/j.metabol.2017.02.002 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, v.70, pp.107 - 115 | - |
dc.identifier.scopusid | 2-s2.0-85014029751 | - |
dc.citation.endPage | 115 | - |
dc.citation.startPage | 107 | - |
dc.citation.title | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.citation.volume | 70 | - |
dc.contributor.affiliatedAuthor | Kim, Mi-hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Isonitramine | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | alpha-glucosidase | - |
dc.subject.keywordAuthor | alpha-amylase | - |
dc.subject.keywordAuthor | PEPCK | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordPlus | PHOSPHOENOLPYRUVATE CARBOXYKINASE | - |
dc.subject.keywordPlus | ALPHA-GLUCOSIDASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | LEAF EXTRACTS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | ZEBRAFISH | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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