The activin-beta A/BMP-2 chimera AB204 is a strong stimulator of adipogenesis
DC Field | Value | Language |
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dc.contributor.author | Kim, Meejung | - |
dc.contributor.author | Kim, Jong In | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.contributor.author | Choe, Senyon | - |
dc.date.available | 2020-02-27T18:43:45Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1932-6254 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6145 | - |
dc.description.abstract | Several of the bone morphogenetic proteins (BMPs) have been reported to induce white as well as brown adipogenesis. Here, we characterized the adipogenic potential of AB204, a recombinant chimeric protein of activin-aA and BMP-2, in in vitro, ex vivo and in vivo settings. BMP-2 is generally known to promote adipogenesis. When compared with BMP-2, which previously showed varying degrees of adipogenesis, AB204 displayed superior in vitro adipogenic differentiation of mouse 3 T3-L1 pre-adipocytes and human adipose-derived stem cells (hASCs). Surprisingly, implantation of hASCs, preconditioned with AB204 for as short a time as 48 h, into the subcutaneous space of athymic nude mice effectively produced fat pads, but not with BMP-2. When BMP-2 and AB204 were injected intraperitoneally, AB204 promoted dramatic systemic adipogenesis of C57BL/6 mice on a high-fat diet very effectively. The results implicate the novel clinical potential of AB204, including induction of fat tissue ex vivo or in vivo for tissue re-engineering and regenerative medicinal purposes, more than any known natural protein ligand. Copyright (C) 2015 John Wiley & Sons, Ltd. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.subject | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject | PLURIPOTENT STEM-CELLS | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | BROWN ADIPOGENESIS | - |
dc.subject | ADIPOCYTE LINEAGE | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | OBESITY | - |
dc.subject | FAT | - |
dc.subject | COMMITMENT | - |
dc.subject | ORIGIN | - |
dc.title | The activin-beta A/BMP-2 chimera AB204 is a strong stimulator of adipogenesis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000402987500019 | - |
dc.identifier.doi | 10.1002/term.2050 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.11, no.5, pp.1524 - 1531 | - |
dc.identifier.scopusid | 2-s2.0-85019864021 | - |
dc.citation.endPage | 1531 | - |
dc.citation.startPage | 1524 | - |
dc.citation.title | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kim, Meejung | - |
dc.contributor.affiliatedAuthor | Choe, Senyon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | BMP | - |
dc.subject.keywordAuthor | TGF beta | - |
dc.subject.keywordAuthor | adipogenesis | - |
dc.subject.keywordAuthor | adipose-derived stem cells | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | PLURIPOTENT STEM-CELLS | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | BROWN ADIPOGENESIS | - |
dc.subject.keywordPlus | ADIPOCYTE LINEAGE | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | COMMITMENT | - |
dc.subject.keywordPlus | ORIGIN | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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