The activin-beta A/BMP-2 chimera AB204 is a strong stimulator of adipogenesis
- Authors
- Kim, Meejung; Kim, Jong In; Kim, Jae Bum; Choe, Senyon
- Issue Date
- May-2017
- Publisher
- WILEY
- Keywords
- BMP; TGF beta; adipogenesis; adipose-derived stem cells
- Citation
- JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.11, no.5, pp.1524 - 1531
- Journal Title
- JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- Volume
- 11
- Number
- 5
- Start Page
- 1524
- End Page
- 1531
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6145
- DOI
- 10.1002/term.2050
- ISSN
- 1932-6254
- Abstract
- Several of the bone morphogenetic proteins (BMPs) have been reported to induce white as well as brown adipogenesis. Here, we characterized the adipogenic potential of AB204, a recombinant chimeric protein of activin-aA and BMP-2, in in vitro, ex vivo and in vivo settings. BMP-2 is generally known to promote adipogenesis. When compared with BMP-2, which previously showed varying degrees of adipogenesis, AB204 displayed superior in vitro adipogenic differentiation of mouse 3 T3-L1 pre-adipocytes and human adipose-derived stem cells (hASCs). Surprisingly, implantation of hASCs, preconditioned with AB204 for as short a time as 48 h, into the subcutaneous space of athymic nude mice effectively produced fat pads, but not with BMP-2. When BMP-2 and AB204 were injected intraperitoneally, AB204 promoted dramatic systemic adipogenesis of C57BL/6 mice on a high-fat diet very effectively. The results implicate the novel clinical potential of AB204, including induction of fat tissue ex vivo or in vivo for tissue re-engineering and regenerative medicinal purposes, more than any known natural protein ligand. Copyright (C) 2015 John Wiley & Sons, Ltd.
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