Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity
- Authors
- Phan Van Kiem; Le Thi Huyen; Dan Thuy Hang; Nguyen Xuan Nhiem; Bui Huu Tai; Hoang Le Tuan Anh; Pham Van Cuong; Tran Hong Quang; Chau Van Minh; Nguyen Van Dau; Kim, Young-A; Subedi, Lalita; Kim, Sun Yeou; Kim, Seung Hyun
- Issue Date
- 1-Apr-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Smenospongia cerebriformis; Sesquiterpene derivative; Smenohaimiens A-E; Anti-inflammation
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.7, pp.1525 - 1529
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 7
- Start Page
- 1525
- End Page
- 1529
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6230
- DOI
- 10.1016/j.bmcl.2017.02.040
- ISSN
- 0960-894X
- Abstract
- Using various chromatographic methods, five new sesquiterpene derivatives named smenohaimiens A-E (1-5) and five known, 19-hydroxy-polyfibrospongol B (6), ilimaquinone (7), dictyoceratin C (8), polyfibrospongol A (9), and polyfibrospongol B (10) were isolated from the marine sponge Smenospongia cerebriformis Duchassaing & Michelotti, 1864. Their structures were assigned by 1D, 2D NMR spectroscopic analysis, HR ESI MS, and calculations of the electron circular dichroism spectra. All compounds were evaluated for the inhibitory activity against NO production in lipopolysaccharide-stimulated in BV2 microglia cells. As the results, compound 7 significantly inhibited NO production with the IC50 value of 10.40 +/- 1.28 mu M. The remaining compounds showed moderate inhibitory NO production activities with IC50 values ranging from 24.37 to 30.43 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
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