Secoiridoid Glucosides from the Twigs of Syringa oblata var. dilatata and Their Neuroprotective and Cytotoxic Activities
- Authors
- Park, Kyoung Jin; Suh, Won Se; Subedi, Lalita; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Apr-2017
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Syringa oblata var. dilatata; Oleaceae; secoiridoid glucoside; nerve growth factor; cytotoxicity
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.65, no.4, pp.359 - 364
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 65
- Number
- 4
- Start Page
- 359
- End Page
- 364
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6264
- DOI
- 10.1248/cpb.c16-00804
- ISSN
- 0009-2363
- Abstract
- Phytochemical investigation of the twigs of Syringa oblata var. diatata led to the isolation of two new secoiridoid glucosides, dilatioside A-B (1-2), along with thirteen known ones (3-15). The structures were determined by spectroscopic methods including one and two dimensional (1-and 2D-) NMR techniques, high resolution (HR)-FAB-MS, and chemical methods. The isolated compounds (1-15) were tested for the induction of nerve growth factor (NGF) secretion in a C6 rat glioma cell line and their cytotoxicity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, HCT15) in vitro using a sulforhodamine B bioassay. Compounds 5, 7, 8, 10, and 14 were found to induce upregulation of NGF secretion without causing significant cell toxicity.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.