The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet
- Authors
- Kim, Min Hee; Lee, Jongsung; Jung, Sehyun; Kim, Joo Wan; Shin, Jae-Ho; Lee, Hae-Jeung
- Issue Date
- Apr-2017
- Publisher
- KOREAN SOC GINSENG
- Keywords
- blood coagulation; blood flow; ginseng berry; high-fat diet; lipid metabolite
- Citation
- JOURNAL OF GINSENG RESEARCH, v.41, no.2, pp.120 - 126
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 41
- Number
- 2
- Start Page
- 120
- End Page
- 126
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6275
- DOI
- 10.1016/j.jgr.2016.01.004
- ISSN
- 1226-8453
- Abstract
- Background: The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via the regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD). Methods: Sixty rats were divided into five groups in descending order of body weight. Except for the control group, the other four groups were fed a HFD containing 45% kcal from fat for 11 wk without GBx. GBx groups were then additionally treated by gastric gavage with GBx dissolved in distilled water at 50 (GBx 50) mg/kg, 100 (GBx 100) mg/kg, or 150 (GBx 150) mg/kg body weight for 6 wk along with the HFD. To investigate the effects of GBx on rats fed a HFD, biochemical metabolite, blood coagulation assay, and histological analysis were performed. Results: In the experiments to measure the serum levels of leptin and apolipoprotein B/A, GBx treatment attenuated the HFD-induced increases in these metabolites (p < 0.05). Adiponectin and apolipoprotein E levels in GBx-treated groups were significantly higher than the HFD group. Prothrombin time and activated partial thromboplastin time were increased in all GBx-treated groups. In the GBx-treated groups, the serum levels of thromboxane A(2) and serotonin were decreased and concentrations of serum fibrinogen degradation products were increased (p < 0.05). Moreover, histomorphometric dyslipidemia-related atherosclerotic changes were significantly improved by treatment with GBx. Conclusion: These results suggest the possibility that GBx can ameliorate blood flow by decreasing intima-media thickness via the regulation of blood coagulation factors related to lipid metabolites in rats fed a HFD. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
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