Development of simple and sensitive hydrogel based colorimetric sensor array for the real-time quantification of gaseous ammonia
- Authors
- Krishnan, Sanduru Thamarai; Son, Kuk Hui; Kim, Namhyoung; Viswanath, Buddolla; Kim, Sanghyo; An, Jeong Ho
- Issue Date
- 1-Mar-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Breath; Ammonia; Detection; Real-time colorimetric sensor array; Limit of detection
- Citation
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.72, pp.583 - 589
- Journal Title
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
- Volume
- 72
- Start Page
- 583
- End Page
- 589
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6318
- DOI
- 10.1016/j.msec.2016.11.112
- ISSN
- 0928-4931
- Abstract
- A real-time colorimetric sensor array (CSA) offers the advantages of diversity and accuracy for the quantification of multiple analytes; however, traditional sensors require a complex fabrication process. Therefore, to take full advantage of this sensing platform, we have developed a simple CSA system composed of a polymer, a reducing agent, and different pH indicators. Distinctive color response patterns were classified by extracting the hidden information, (i.e., red, green, and blue (RGB) values) from the indicators. This triple-channel sensing platform is further applied for statistical analysis, to quantify different concentrations of ammonia and other analytes. The sensor array showed a limit of detection of 0.3 ppm, which is well below the diagnostic criteria for ammonia concentration in the breath of healthy individuals and of patients with end-stage renal disease. As this sensor would be able to quantify gaseous ammonia in the breath, it is relevant to the point-of-care diagnosis of patients with renal diseases. (C) 2016 Elsevier B.V. All rights reserved.
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- 의과대학 > 의학과 > 1. Journal Articles
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