Number of branch points in alpha-limit dextrins impact glucose generation rates by mammalian mucosal alpha-glucosidases
- Authors
- Lee, Byung-Hoo; Hamaker, Bruce R.
- Issue Date
- 10-Feb-2017
- Publisher
- ELSEVIER SCI LTD
- Keywords
- alpha-limit dextrins; Starch; Slow digestion; alpha-glucosidases Human; alpha-amylase
- Citation
- CARBOHYDRATE POLYMERS, v.157, pp.207 - 213
- Journal Title
- CARBOHYDRATE POLYMERS
- Volume
- 157
- Start Page
- 207
- End Page
- 213
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6400
- DOI
- 10.1016/j.carbpol.2016.09.088
- ISSN
- 0144-8617
- Abstract
- alpha-Amylase first hydrolyzes starch structures to linear maltooligosaccharides and branched alpha-limit dextrins, then complete hydrolysis to glucose takes place through the mucosal alpha-glucosidases. In this study, we hydrolyzed waxy corn starch (WCS) by human pancreatic alpha-amylase to determine the digestion and structural properties of different size fractions of the branched alpha-limit dextrins. The alpha-amylolyzed WCS was separated by size exclusion chromatography, and the analyzed chromatograms showed four main hydrolyzate fractions. The first three eluted peaks (regions I-III) corresponded to branched alpha-limit dextrins, while region IV was the linear maltooligosaccharides. Based on the chromatographic and NMR analyses of the individual peaks, Region I, II, and III had multiple (>2), two, and one alpha-1,6 linkages, respectively, and region I was the most slowly hydrolyzed to glucose by mucosal alpha-glucosidases (hydrolysis rate: Region I < II < III < IV). This study shows the possibility of producing slowly digestible oligosaccharides that may decrease postprandial glycemic response and control glucose delivery to the body, to address metabolic syndrome-associated diseases. (C) 2016 Published by Elsevier Ltd.
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