Anti-Neurodegenerative Biflavonoid Glycosides from Impatiens balsamina
- Authors
- Kim, Chung Sub; Bae, Munhyung; Oh, Joonseok; Subedi, Lalita; Suh, Won Se; Choi, Sang Zin; Son, Mi Won; Kim, Sun Yeou; Choi, Sang Un; Oh, Dong-Chan; Lee, Kang Ro
- Issue Date
- Feb-2017
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.80, no.2, pp.471 - 478
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 80
- Number
- 2
- Start Page
- 471
- End Page
- 478
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6415
- DOI
- 10.1021/acs.jnatprod.6b00981
- ISSN
- 0163-3864
- Abstract
- Four biflavonoid glycosides, balsamisides A-D (1-4), and nine known compounds (5-13) were obtained from the white petals of Impatiens balsamina. The 2D structures of the purified phytochemicals were established using conventional NMR techniques in addition to the new long-range HSQMBC NMR experiment. Acid hydrolysis followed by experimental and quantum-mechanics-based ECD data analysis permitted full configurational assignment of the purified metabolites. Compounds 1-13 were assessed for their potential to impede the generation of nitric oxide in lipopolysaccharide-stimulated BV2 cells. They were also investigated for potential neuroprotective activity using C6 cells and cytotoxicity against some human tumor cell lines, but were inactive (IC50 > 10 mu M) against all the cell lines.
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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