Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study
- Authors
- Lee, Jung Sun; Kwon, Jun Soo; Kim, Daeho; Kim, Sung-Wan; Kim, Jae-Jin; Kim, Jong-Noon; Nam, Hee Jung; Ryu, Seunghyong; Park, Il Ho; An, Suk Kyoon; Oh, Hong-Seok; Won, Seunghee; Lee, Kanguk; Lee, Young; Lee, Seung-Hwan; Lee, Yu Sang; Yi, Jung-Seo; Hong, Kyung Sue; Joo, Yeon Ho
- Issue Date
- Jan-2017
- Publisher
- KOREAN NEUROPSYCHIATRIC ASSOC
- Keywords
- Metabolic syndrome; Antipsychotics; Korean population; Schizophrenia; Schizoaffective disorder
- Citation
- PSYCHIATRY INVESTIGATION, v.14, no.1, pp.44 - 50
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 14
- Number
- 1
- Start Page
- 44
- End Page
- 50
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6550
- DOI
- 10.4306/pi.2017.14.1.44
- ISSN
- 1738-3684
- Abstract
- Objective We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. Methods This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013. MetS was diagnosed using the criteria of the modified Adult Treatment Panel III of the National Cholesterol Education Program with the Korean abdominal obesity definition (waist circumference >= 85 cm in women, >= 90 cm in men). Results The prevalence of MetS in all patients was 36.5% and was significantly higher in men than women (men, 40.8%; women, 32.2%) and was significantly correlated with age [odds ratio (OR) 1.02] and duration of illness (OR 1.03). The prevalence of MetS across antipsychotic drugs in the major monotherapy group was as follows: 18.8% for quetiapine, 22.0% for aripiprazole, 33.3% for both amisulpride and paliperidone, 34.0% for olanzapine, 35% for risperidone, 39.4% for haloperidol, and 44.7% for dozapine. Conclusion The prevalence of MetS is very high in patients with schizophrenia or schizoaffective disorder. Screening and monitoring of MetS is also strongly recommended.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6550)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.