Protective effects of Bifidobacterium bifidum culture supernatants and intracellular cell-free extracts on human dermal fibroblasts against UV-B irradiation
DC Field | Value | Language |
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dc.contributor.author | Gwon, G.Y. | - |
dc.contributor.author | Park, G.G. | - |
dc.date.available | 2020-02-27T20:42:00Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1226-3311 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6625 | - |
dc.description.abstract | The present study investigated the protective effects of Bifidobacterium bifidum culture supernatants (BbSC) and intracellular cell-free extracts (BbICFE) on human dermal fibroblasts (HDFs) against ultraviolet-B (UV-B) irradiation. HDFs were treated with UV-B, UV-B+BbCS, and UV-B+BbICFE. Treatment of UV-B-irradiated HDFs with BbCS and BbICFE significantly increased cell viability compared to UV-B-irradiated HDFs. BbCS treatment reduced senescence in HDFs by approximately 40.0%. Moreover, sub-G1 phase was significantly reduced in BbCS-and BbICFE-treated HDFs (3.3% and 4.5%, respectively). The effect of UV-B on oxidative damage of HDFs was measured by dichlorofluorescin diacetate. Fluorescence intensity significantly increased in UV-B-irradiated HDFs. Inhibition of cellular reactive oxygen species in HDFs treated with 0.01% BbCS was the highest at 34.1%. Levels of p21 and p53 protein expression induced by UV-B irradiation were reduced by treatment with BbCS and BbICFE (47.0% and 35.6%, respectively). These results show that BbCS and BbICFE reduce UV-B-induced cellular senescence and apoptosis in HDFs. Thus, BbCS and BbICFE can be used as potential agents for protection of UV-B-induced skin cell damage. © 2017, Korean Society of Food Science and Nutrition. All rights reserved. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | Korean Society of Food Science and Nutrition | - |
dc.relation.isPartOf | Journal of the Korean Society of Food Science and Nutrition | - |
dc.title | Protective effects of Bifidobacterium bifidum culture supernatants and intracellular cell-free extracts on human dermal fibroblasts against UV-B irradiation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.3746/jkfn.2017.46.7.801 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Food Science and Nutrition, v.46, no.7, pp.801 - 808 | - |
dc.identifier.kciid | ART002248444 | - |
dc.identifier.scopusid | 2-s2.0-85026997510 | - |
dc.citation.endPage | 808 | - |
dc.citation.startPage | 801 | - |
dc.citation.title | Journal of the Korean Society of Food Science and Nutrition | - |
dc.citation.volume | 46 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Gwon, G.Y. | - |
dc.contributor.affiliatedAuthor | Park, G.G. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Bifidobacterium bifidum | - |
dc.subject.keywordAuthor | Culture supernatants | - |
dc.subject.keywordAuthor | Human dermal fibroblasts | - |
dc.subject.keywordAuthor | Intracellular cell free extracts | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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