관절염 치료 보조제로서 커큐민의 유효성 및 안전성에 대한 문헌고찰

Abstract

Curcumin has excellent antioxidant and anti-inflammatory properties and is used for the prevention and treatmentof various diseases. It has recently been developed as a health supplement and widely available worldwide. In particular,curcumin-containing preparations are used as health-functional foods for arthritis patients and semi-healthy persons,but detailed clinical data related to them are not well-recognized in Korea. In this article, data on the safety and efficacy ofcurcumin for joint and bone health-related efficacy were collected via Pubmed and Clinical Trials.gov databases, which areadministered by the US National Library of Medicine. A total of 126 articles were searched in the Pubmed and Clinicaltrials. gov databases. Four records of the articles were clinically related with knee osteoarthritis. Three of the four clinicaltrials collected were phase 2 studies with a prospective randomized double-blind placebo-controlled trial, and one phase 3study with a prospective randomized double-blind, active, comparator trial. Analysis of these four clinical trial data showedthat introduction of curcumin as a preventive and therapeutic adjunct to osteoarthritis could be a treatment alternative forosteoarthritis patients. However, the clinical data published so far have not been enough to show the validity of the results. Therefore, a broader clinical trial for the efficacy and safety of curcumin as an adjuvant for treating osteoarthritis is warranted.