비만 쥐의 식이제한과 유산소운동이 시상하부의 염증, 식욕억제 Neuropeptide 및 하루식이섭취량에 미치는 영향

Abstract

This study was conducted to investigate the effects of calorie restriction and aerobic exercise on expression of appetite suppression neuropeptide, inflammation factors in hypothalamus and daily feed intake of obese mouse. Obesity was induced in C57BL/6 male mice (n=60) by high-fat diet, which were divided into six experimental groups, control group (CG), high-fat diet group (HDG), normal diet group (NDG), normal diet and aerobic exercise group (NDEG), calorie restriction group (CRG), calorie restriction and aerobic exercise group (CREG). Calorie restriction and/or aerobic exercise of 12 weeks were treated, and as a result of analysis of dependent variables, the following conclusion was induced. After completion of experiment, CREG was shown to be effective in weight reduction compared with other groups. and average daily feed intake was shown less after completion of experiment than high-fat diet group (HDG), normal diet group (NDG) and calorie restriction group (CRG). Also, as manifestation of IL-6 in the hypothalamus was shown significantly higher compared with other groups. the affirmative effect in synaptic transmission of signal related to appetite suppression and energy consumption by increase of IL-6 in the hypothalamus due to aerobic exercise was confirmed. On the contrary, although, in HDG, concentration of leptin expression levels in the hypothalamus were shown significantly lower, leptin resistance may be confirmed. and TNF-α expression level was shown significantly more than other groups. As a result, by IL-6 in the hypothalamus as reaction to aerobic exercise and calorie restriction in treatment with leptin resistance in obesity, the effect of weight reduction was confirmed.