STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels - The Orai-STIM1-TRPC Complexes
DC Field | Value | Language |
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dc.contributor.author | Bodnar, Dora | - |
dc.contributor.author | Chung, Woo Young | - |
dc.contributor.author | Yang, Dongki | - |
dc.contributor.author | Hong, Jeong Hee | - |
dc.contributor.author | Jha, Archana | - |
dc.contributor.author | Muallem, Shmuel | - |
dc.date.available | 2020-02-27T23:42:06Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7510 | - |
dc.description.abstract | Ca2+ influx by plasma membrane Ca2+ channels is the crucial component of the receptor-evoked Ca2+ signal. The two main Ca2+ influx channels of non-excitable cells are the Orai and TRPC families of Ca2+ channels. These channels are activated in response to cell stimulation and Ca2+ release from the endoplasmic reticulum (ER). The protein that conveys the Ca2+ content of the ER to the plasma membrane is the ER Ca2+ sensor STIM1. STIM1 activates the Orai channels and is obligatory for channel opening. TRPC channels can function in two modes, as STIM1-dependent and STIM1-independent. When activated by STIM1, both channel types function at the ER/ PM (plasma membrane) junctions. This chapter describes the properties and regulation of the channels by STIM1, with emphasis how and when TRPC channels function as STIM1-dependent and STIM1-independent modes and their unique Ca2+-dependent physiological functions that are not shared with the Orai channels. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER INTERNATIONAL PUBLISHING AG | - |
dc.relation.isPartOf | STORE-OPERATED CA2+ ENTRY (SOCE) PATHWAYS: EMERGING SIGNALING CONCEPTS IN HUMAN (PATHO)PHYSIOLOGY, 2ND EDITION | - |
dc.title | STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels - The Orai-STIM1-TRPC Complexes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000438260900009 | - |
dc.identifier.doi | 10.1007/978-3-319-57732-6_8 | - |
dc.identifier.bibliographicCitation | STORE-OPERATED CA2+ ENTRY (SOCE) PATHWAYS: EMERGING SIGNALING CONCEPTS IN HUMAN (PATHO)PHYSIOLOGY, 2ND EDITION, v.993, pp.139 - 157 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85029507901 | - |
dc.citation.endPage | 157 | - |
dc.citation.startPage | 139 | - |
dc.citation.title | STORE-OPERATED CA2+ ENTRY (SOCE) PATHWAYS: EMERGING SIGNALING CONCEPTS IN HUMAN (PATHO)PHYSIOLOGY, 2ND EDITION | - |
dc.citation.volume | 993 | - |
dc.contributor.affiliatedAuthor | Yang, Dongki | - |
dc.contributor.affiliatedAuthor | Hong, Jeong Hee | - |
dc.type.docType | Article; Book Chapter | - |
dc.subject.keywordAuthor | TRPC channels | - |
dc.subject.keywordAuthor | Orai channels | - |
dc.subject.keywordAuthor | STIM1 | - |
dc.subject.keywordAuthor | Complexes | - |
dc.subject.keywordAuthor | Regulation | - |
dc.subject.keywordAuthor | ER-PM junctions | - |
dc.subject.keywordPlus | OPERATED CALCIUM-ENTRY | - |
dc.subject.keywordPlus | STROMAL INTERACTION MOLECULE-1 | - |
dc.subject.keywordPlus | ER-PM JUNCTIONS | - |
dc.subject.keywordPlus | PLASMA MEMBRANE JUNCTIONS | - |
dc.subject.keywordPlus | PANCREATIC ACINAR-CELL | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | ORAI CHANNELS | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | STORE DEPLETION | - |
dc.subject.keywordPlus | CRAC CHANNEL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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