STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels - The Orai-STIM1-TRPC Complexes
- Authors
- Bodnar, Dora; Chung, Woo Young; Yang, Dongki; Hong, Jeong Hee; Jha, Archana; Muallem, Shmuel
- Issue Date
- Sep-2017
- Publisher
- SPRINGER INTERNATIONAL PUBLISHING AG
- Keywords
- TRPC channels; Orai channels; STIM1; Complexes; Regulation; ER-PM junctions
- Citation
- STORE-OPERATED CA2+ ENTRY (SOCE) PATHWAYS: EMERGING SIGNALING CONCEPTS IN HUMAN (PATHO)PHYSIOLOGY, 2ND EDITION, v.993, pp.139 - 157
- Journal Title
- STORE-OPERATED CA2+ ENTRY (SOCE) PATHWAYS: EMERGING SIGNALING CONCEPTS IN HUMAN (PATHO)PHYSIOLOGY, 2ND EDITION
- Volume
- 993
- Start Page
- 139
- End Page
- 157
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7510
- DOI
- 10.1007/978-3-319-57732-6_8
- ISSN
- 0065-2598
- Abstract
- Ca2+ influx by plasma membrane Ca2+ channels is the crucial component of the receptor-evoked Ca2+ signal. The two main Ca2+ influx channels of non-excitable cells are the Orai and TRPC families of Ca2+ channels. These channels are activated in response to cell stimulation and Ca2+ release from the endoplasmic reticulum (ER). The protein that conveys the Ca2+ content of the ER to the plasma membrane is the ER Ca2+ sensor STIM1. STIM1 activates the Orai channels and is obligatory for channel opening. TRPC channels can function in two modes, as STIM1-dependent and STIM1-independent. When activated by STIM1, both channel types function at the ER/ PM (plasma membrane) junctions. This chapter describes the properties and regulation of the channels by STIM1, with emphasis how and when TRPC channels function as STIM1-dependent and STIM1-independent modes and their unique Ca2+-dependent physiological functions that are not shared with the Orai channels.
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