Effect of Influenza Vaccination on Risk of Stroke: A Systematic Review and Meta-Analysis
- Authors
- Lee, Kyu Rae; Bae, Jeong Hun; Hwang, In Cheol; Kim, Kyoung Kon; Suh, Heuy Sun; Ko, Ki Dong
- Issue Date
- Aug-2017
- Publisher
- KARGER
- Keywords
- Influenza vaccination; Influenza; Stroke
- Citation
- NEUROEPIDEMIOLOGY, v.48, no.3-4, pp.103 - 110
- Journal Title
- NEUROEPIDEMIOLOGY
- Volume
- 48
- Number
- 3-4
- Start Page
- 103
- End Page
- 110
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7524
- DOI
- 10.1159/000478017
- ISSN
- 0251-5350
- Abstract
- Background: Despite the presence of a strong association between influenza infection and stroke, whether influenza vaccination reduces the risk of stroke is yet a matter of controversy. We conducted a meta-analysis to determine whether influenza vaccination protects against stroke. Methods: We searched PubMed, EMBASE, and the Cochrane Library from database inception date to November 18, 2016, without language restrictions, to identify studies investigating the effect of influenza vaccination on subsequent risk of stroke. We conducted a meta-analysis to quantify the risk of stroke in overall and subgroup analyses and calculated a pooled OR for developing stroke with a 95% CI. Publication bias was assessed by Begg's rank correlation test. Results: Eleven studies fulfilled our inclusion criteria. In a random-effects model, vaccinated individuals had a decreased risk of stroke compared with unvaccinated individuals (OR 0.82; 95% CI 0.75-0.91; p < 0.001). The relationship between influenza vaccination and stroke risk remained robust in subgroup analyses. The significant effect of influenza vaccination was associated with ascertainment of vaccination status and stage of prevention. Conclusion: Vaccination against in- fluenza is associated with a lower risk of stroke. Well-designed prospective studies are needed to provide stronger evidence of the protective effect of influenza vaccination against stroke. (C) 2017 S. Karger AG, Basel
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7524)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.