Detailed Information
Cited 30 time in 
Cited 32 time in 
Cited 32 time in
Metadata Downloads
Detection of HIV-1 antigen by quartz crystal microbalance using gold nanoparticles
- Authors
- Tan Nhiem Ly; Park, Sangkwon; Park, Sang Joon
- Issue Date
- Dec-2016
- Publisher
- ELSEVIER SCIENCE SA
- Keywords
- HIV-1 antigen; Quartz crystal microbalance; Gold nanoparticles; Early detection; Signal amplification
- Citation
- SENSORS AND ACTUATORS B-CHEMICAL, v.237, pp.452 - 458
- Journal Title
- SENSORS AND ACTUATORS B-CHEMICAL
- Volume
- 237
- Start Page
- 452
- End Page
- 458
- ISSN
- 0925-4005
- Abstract
- In the current exploratory study, a quartz crystal microbalance (QCM) technique was employed to detect HIV-1 antigen at a very low concentration using gold nanoparticles (Au NPs) as a signal enhancer. Colloidal Au NPs were synthesized using a reduction method followed by streptavidin functionalization. HIV-1 antigen was captured by a polyclonal antibody on the QCM surface that had been previously treated with 11-mercaptoundecanoicacid (MUA) and streptavidin. The Au NPs with a high mass amplified the detection signal, making HIV-1 antigen detection possible even in the window period of HIV infection. In addition, the effect of Au NP size was also investigated to elucidate the optimal size of the enhancer. The signal performance is discussed in terms of mass effect and conjugate efficiency. (C) 2016 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 공과대학 > 화공생명공학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Park, Sang Joon
- Engineering (Department of Chemical and Biological Engineering)