Impedimetric Tumor Necrosis Factor-alpha Sensor Based on a Reduced Graphene Oxide Nanoparticle-Modified Electrode Array
- Authors
- Yagati, Ajay Kumar; Lee, Ga-Yeon; Ha, Sungji; Chang, Keun-A; Pyun, Jae-Chul; Cho, Sungbo
- Issue Date
- Nov-2016
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Graphene Oxide; Nanoparticle; Tumor Necrosis Factor-alpha; Impedance; Biosensor
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.16, no.11, pp.11921 - 11927
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 16
- Number
- 11
- Start Page
- 11921
- End Page
- 11927
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7734
- DOI
- 10.1166/jnn.2016.13618
- ISSN
- 1533-4880
- Abstract
- A surface was prepared by simple electrodeposition of reduced graphene oxide (RGO) coated with gold nanoparticles (AuNP) on an indium tin oxide microelectrode array, and its ability and applicability in a tumor necrosis factor-alpha (TNF-alpha) detection sensor was evaluated by electrochemical impedance spectroscopy (EIS). The AuNP-RGO hybrid structure showed improved electrical conductivity when compared with the conductivities of its individual elements and demonstrated an excellent capturing ability for TNF-alpha antibody-antigen binding. A quantitative determination of the TNF-alpha detection performance was achieved by measuring the resistance changes with varying TNF-alpha concentrations while using a [Fe(CN)(6)](3-/4-) redox probe in EIS. The antibody covered electrode resistance increases approximately linearly (r = 0.969) with increasing antigen concentration. The proposed TNF-alpha sensor has a 0.43 pg mL(-1) minimum detection limit and a linear range of 1-1000 pg mL(-1).
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