Protection Effect of Punicalagin Isolated from Pomegranate on Inflammation and Ethanol-induced Gastric Mucosal Injury
DC Field | Value | Language |
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dc.contributor.author | Lee, Hye Lim | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-28T00:41:31Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7743 | - |
dc.description.abstract | Excessive alcohol consumption is one of the most common causes of gastritis. The activation of cyclooxygenase-2 (COX-2), associated with reactive oxygen species, is a key process in the inflammatory response of ethanol-induced gastritis. Punicalagin, a naturally occurring active ingredient of pomegranate, is a potential antioxidant. In this study, pomegranate extract and punicalagin exhibited free radical scavenging activity in a dose-dependent manner. Pretreatment with pomegranate extract also exerted gastroprotective effects by reducing the inflammatory response to ethanol-induced gastric mucosal damage. Furthermore, punicalagin inhibited the expression of inflammatory COX-2 by suppressing the activation of mitogen-activated protein kinases in lipopolysaccharide-induced inflammation. These findings suggest that punicalagin may be beneficial for the prevention and/or treatment of gastric inflammation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | RAW 264.7 MACROPHAGES | - |
dc.subject | CANCER CELLS | - |
dc.subject | COX-2 EXPRESSION | - |
dc.subject | IN-VITRO | - |
dc.subject | ACTIVATION | - |
dc.subject | JNK | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | SUPPRESSION | - |
dc.subject | MECHANISMS | - |
dc.title | Protection Effect of Punicalagin Isolated from Pomegranate on Inflammation and Ethanol-induced Gastric Mucosal Injury | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000387390600009 | - |
dc.identifier.doi | 10.1002/bkcs.10973 | - |
dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.11, pp.1778 - 1782 | - |
dc.identifier.kciid | ART002163911 | - |
dc.identifier.scopusid | 2-s2.0-84990250680 | - |
dc.citation.endPage | 1782 | - |
dc.citation.startPage | 1778 | - |
dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.citation.volume | 37 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Lee, Hye Lim | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Gastritis | - |
dc.subject.keywordAuthor | Cyclooxygenase | - |
dc.subject.keywordAuthor | Punicalagin | - |
dc.subject.keywordAuthor | Pomegranate | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RAW 264.7 MACROPHAGES | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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