Protection Effect of Punicalagin Isolated from Pomegranate on Inflammation and Ethanol-induced Gastric Mucosal Injury
- Authors
- Lee, Hye Lim; Kang, Ki Sung
- Issue Date
- Nov-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Gastritis; Cyclooxygenase; Punicalagin; Pomegranate; Inflammation
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.11, pp.1778 - 1782
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 37
- Number
- 11
- Start Page
- 1778
- End Page
- 1782
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7743
- DOI
- 10.1002/bkcs.10973
- ISSN
- 0253-2964
- Abstract
- Excessive alcohol consumption is one of the most common causes of gastritis. The activation of cyclooxygenase-2 (COX-2), associated with reactive oxygen species, is a key process in the inflammatory response of ethanol-induced gastritis. Punicalagin, a naturally occurring active ingredient of pomegranate, is a potential antioxidant. In this study, pomegranate extract and punicalagin exhibited free radical scavenging activity in a dose-dependent manner. Pretreatment with pomegranate extract also exerted gastroprotective effects by reducing the inflammatory response to ethanol-induced gastric mucosal damage. Furthermore, punicalagin inhibited the expression of inflammatory COX-2 by suppressing the activation of mitogen-activated protein kinases in lipopolysaccharide-induced inflammation. These findings suggest that punicalagin may be beneficial for the prevention and/or treatment of gastric inflammation.
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