Demethyleugenol beta-Glucopyranoside Isolated from Agastache rugosa Decreases Melanin Synthesis via Down-regulation of MITF and SOX9
DC Field | Value | Language |
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dc.contributor.author | Lee, Taek Hwan | - |
dc.contributor.author | Park, SeonJu | - |
dc.contributor.author | Yoo, Guijae | - |
dc.contributor.author | Jang, Cheongyun | - |
dc.contributor.author | Kim, Mi-hyun | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.date.available | 2020-02-28T00:42:12Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-10-19 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7784 | - |
dc.description.abstract | Agastache rugosa (Fisch & C. A. Mey.) Kuntze has been well-known for its antioxidative properties. This study investigated the anti-melanogenesis effect of demethyleugenol beta-D-glucopyranoside (1) from A. rugosa by studying molecular regulation of melanogenesis in melan-a mouse melanocytes and normal human epidermal melanocytes (NHEMs) and, in in vivo. models. The SRY (sex-determining region on the Y chromosome)-related high-mobility group (HMG) box 9 (SOX9), one of the critical factors that affect skin pigmentation, is up-regulated. Interestingly, 1 down-regulated the expression of SOX9 and microphthalmia-associated transcription factor (MITF). Reduction of these two transcription factors resulted in a decrease in-melanogenic enzymes such as tyrosinase, tyrosinase-related protein 1, and dopachrome tautomerase. As a result, 1 significantly inhibited melanin synthesis in melan-a mouse melanocytes and NHEMs. In addition, the anti-melanogenic effect of 1 was confirmed in zebrafish and reconstructed skin tissue models. In conclusion, 1, as a potent SOX9 regulator, ameliorates skin pigmentation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.subject | HUMAN MELANOCYTES | - |
dc.subject | TYROSINASE | - |
dc.subject | CELLS | - |
dc.subject | PIGMENTATION | - |
dc.subject | GLYCOSIDES | - |
dc.subject | ZEBRAFISH | - |
dc.subject | PHENYLTHIOUREA | - |
dc.subject | RESVERATROL | - |
dc.subject | INHIBITION | - |
dc.subject | PROMOTER | - |
dc.title | Demethyleugenol beta-Glucopyranoside Isolated from Agastache rugosa Decreases Melanin Synthesis via Down-regulation of MITF and SOX9 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000385991900008 | - |
dc.identifier.doi | 10.1021/acs.jafc.6b03256 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.41, pp.7733 - 7742 | - |
dc.identifier.scopusid | 2-s2.0-84992184132 | - |
dc.citation.endPage | 7742 | - |
dc.citation.startPage | 7733 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 41 | - |
dc.contributor.affiliatedAuthor | Jang, Cheongyun | - |
dc.contributor.affiliatedAuthor | Kim, Mi-hyun | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | demethyleugenol beta-glucopyranoside | - |
dc.subject.keywordAuthor | SOX9 | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | NHEM | - |
dc.subject.keywordAuthor | reconstructed skin | - |
dc.subject.keywordPlus | HUMAN MELANOCYTES | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PIGMENTATION | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | ZEBRAFISH | - |
dc.subject.keywordPlus | PHENYLTHIOUREA | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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