Clinical Impact of PD-L1 Expression for Survival in Curatively Resected Colon Cancer
- Authors
- Jung, D.H.; Park, H.J.; Jang, H.H.; Kim, S.-H.; Jung, Y.; Lee, W.-S.
- Issue Date
- Aug-2020
- Publisher
- Taylor and Francis Ltd
- Keywords
- biochemical markers; Cancer biomarkers; chemotherapy
- Citation
- Cancer Investigation, v.38, no.7, pp.406 - 414
- Journal Title
- Cancer Investigation
- Volume
- 38
- Number
- 7
- Start Page
- 406
- End Page
- 414
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78058
- DOI
- 10.1080/07357907.2020.1793349
- ISSN
- 0735-7907
- Abstract
- Background: Programmed death 1 (PD-1) and its ligand PD-L1 play a key dysfunction of T lymphocytes. The purpose of this study was to assess and compare the prognostic role of tumor- TILs and its relationship with PD-L1 expression in stage II and III colon cancer. Methods: Immunohistochemisty was used to assess the densities of CD8+, CD4+, and FOXP3+ cells, and PD-L1 expression in intraepithelial tumor site from 58 stage II and III colon cancers. These were evaluated for association with histopathologic features and overall survival. Results: PD-L1-positive tumors contained a higher number of CD8+ TILs with statistical significance (p = 0.001). CD4+ TILs showed positive correlation with PD-L1 expression (p = 0.034). There were no associations between PD-L1 expression and FOXP3+ TILs. Microsatellite instability (MSI)-high status (p = 0.001; Odd ration 18.0; 95% CI = 4.3–74.8) was the strongest prognostic factor along with mucinous/poor cell differentiation, CD8 and right tumor location was associated with PD-L1 expression (p = 0.024, 0.035 and 0.033, respectively). Conclusion: This study demonstrated that PD-L1 expression was associated with MSI-high, increased CD8+ TILs, mucinous and poor cell differentiation, and right-sided tumor location. © 2020 The Author(s). Published by Taylor & Francis Group, LLC.
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