Ultrarapid, size-controlled, high-crystalline plasma-mediated synthesis of ceria nanoparticles for reagent-free colorimetric glucose test strips
- Authors
- Ahn H.T.; An H.-R.; Hong Y.C.; Lee S.C.; Le T.N.; Le X.A.; Kwak H.S.; Lee Y.-S.; Jeong Y.; Park J.-I.; Kim H.; Lee M.; Yoo S.J.; Lee S.-G.; Choi K.; Lee Y.-B.; Kim M.I.; Lee H.U.
- Issue Date
- Oct-2020
- Publisher
- Elsevier B.V.
- Keywords
- Ceria nanoparticles; Color-changing property; Paper-based glucose assay; Plasma-mediated synthesis; Point-of-care testing; Reagent-free colorimetric detection
- Citation
- Sensors and Actuators, B: Chemical, v.320
- Journal Title
- Sensors and Actuators, B: Chemical
- Volume
- 320
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78059
- DOI
- 10.1016/j.snb.2020.128404
- ISSN
- 0925-4005
- Abstract
- We describe an ultrarapid (within several minutes), size-controlled (<100 nm in diameter), and high-crystalline plasma-mediated synthesis of ceria nanoparticles and their application in reagent-free colorimetric test strips. Glucose oxidase (GOx) incorporated onto the paper matrix generates H2O2 with glucose, subsequently inducing color changes of the embedded ceria nanoparticles from white/yellow to yellow/orange without any involvement of colorimetric substrate or dye. The optimized protocol yielded ∼2-fold higher color intensity compared to that of commercially available ceria nanoparticles, presumably due to its much larger surface area and higher Ce3+ content, facilitating the oxidation from Ce3+ to Ce4+ and formation of peroxide complexes at the nanoparticle surfaces. Using the colorimetric test strip, glucose was specifically detected over a wide linear range (0.1−10 mM), with excellent reusability, storage stability, precision, and reproducibility. The innovative plasma-mediated ultrarapid synthesis of size-controlled and high-crystalline ceria nanoparticles and their utilization on reagent-free colorimetric test strip allow for a straightforward sensing platform for the point-of-care detection of glucose and can be expanded to other oxidative enzymes for facile colorimetric detection of various clinically important target molecules. © 2020 Elsevier B.V.
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