Radiographic portal or superior mesenteric vein invasion is an independent prognostic factor in non-metastatic pancreatic ductal adenocarcinoma: A missing block of clinical T staging?
- Authors
- Kang H.; Kim S.-S.; Sung M.J.; Jo J.H.; Lee H.S.; Chung M.J.; Park J.Y.; Park S.W.; Song S.Y.; Park M.-S.; Bang S.
- Issue Date
- Jul-2020
- Publisher
- ELSEVIER
- Keywords
- Pancreatic cancer; Portal vein; Prognosis; Staging system; Venous invasion
- Citation
- PANCREATOLOGY, v.20, no.5, pp.952 - 959
- Journal Title
- PANCREATOLOGY
- Volume
- 20
- Number
- 5
- Start Page
- 952
- End Page
- 959
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78075
- DOI
- 10.1016/j.pan.2020.05.017
- ISSN
- 1424-3903
- Abstract
- Background: Venous invasion is not included in the pancreatic ductal adenocarcinoma (PDAC) staging, and its correlation with prognosis remains unclear. We evaluated the prognostic impact of radiographic portal/superior mesenteric vein (PV/SMV) invasion, and its possibility of complementing T staging. Methods: We identified patients with non-metastatic PDAC using our institutional cohort, and divided them according to PV/SMV invasion at imaging, defined as >180-degree tumor-vessel interface or contour deformity. We conducted Cox proportional hazard regression, and compared survival in the original and 1:1 propensity score matched datasets. Results: We identified 454 patients [PV/SMV(+): 172; PV/SMV(−): 282]. In the multivariate analysis, PV/SMV invasion, age (≥70 years), performance status, tumor size (2–4, >4 cm), lymph nodes >4, and arterial invasion was correlated with prognosis. The PV/SMV(+) group had a shorter overall survival (OS) than the PV/SMV(−) group in the original (14.4 vs. 20.9 months; P < 0.001) and matched datasets (14.3 vs. 17.2 months; P = 0.009). Among patients without arterial invasion (cT1–cT3), the PV/SMV(+) group had a shorter OS (15.9 vs. 21.2 months; P = 0.002). Moreover, their OS did not differ from that of patients with arterial invasion (cT4) (15.9 vs. 14.4 months; P = 0.907). Patients with vessel (artery/vein) invasion had a shorter OS than those without vessel invasion (14.5 vs. 21.2 months; P < 0.001). Conclusions: Radiographic PV/SMV invasion in non-metastatic PDAC was correlated with a poor prognosis. It could identify a group with shorter OS among patients without arterial invasion (cT1–cT3). It is suggested that inclusion of PV/SMV invasion in clinical T4 criteria should be considered. © 2020
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78075)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.