Outcomes of decitabine treatment for newly diagnosed acute myeloid leukemia in older adults
- Authors
- Yoo, K.H.; Cho, J.; Han, B.; Kim, S.H.; Shin, D.-Y.; Hong, J.; Kim, H.; Kim, H.J.; Zang, D.Y.; Yoon, S.-S.; Jin, J.-Y.; Lee, J.H.; Hong, D.-S.; Park, S.K.
- Issue Date
- Aug-2020
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PloS one, v.15, no.8, pp.e0235503
- Journal Title
- PloS one
- Volume
- 15
- Number
- 8
- Start Page
- e0235503
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78132
- DOI
- 10.1371/journal.pone.0235503
- ISSN
- 1932-6203
- Abstract
- PURPOSE: We evaluated the outcomes of decitabine as first-line treatment in older patients with acute myeloid leukemia (AML) and investigated the predictors, including a baseline mini nutritional assessment short form (MNA-SF) score, of response and survival. PATIENTS AND METHODS: Between 2010 and 2018, 96 AML patients aged 65 and above who received decitabine treatment at 6 centers in Korea were retrospectively evaluated. Response rates, hematologic improvements (HI), progression-free survival (PFS), and overall survival (OS) were analyzed. RESULTS: The median age at diagnosis was 73.9 years, and the median number of decitabine treatments administered to the patients was 4 (range, 1-29). Of 85 patients, 15 patients (17.6%) achieved complete remission (CR) or CR with incomplete blood count recovery. Twelve patients (14.1%) showed partial remission (PR), and 18 (21.2%) demonstrated HI without an objective response. The median PFS and OS were 7.0 (95% confidence interval [CI], 4.9-9.0) and 10.6 (95% CI, 7.7-13.5%) months, respectively. In multivariate analyses, MNA-SF score ≥ 8 and the absence of peripheral blood (PB) blasts were significant predictors for improved PFS and OS. CONCLUSIONS: For older patients with newly diagnosed AML, a high MNA-SF score and the absence of PB blasts were independently associated with improved survival.
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