세균을 이용한 CP 약침의 복귀돌연변이 시험Bacterial Reverse Mutation Test of CP pharmacopunture
- Other Titles
- Bacterial Reverse Mutation Test of CP pharmacopunture
- Authors
- 황지혜; 구자승; 정철
- Issue Date
- Sep-2020
- Publisher
- 대한한의학회
- Keywords
- CP pharmacopunture; capsaicin; toxicity; bacterial reverse mutation test; acupuncture
- Citation
- 대한한의학회지, v.41, no.3, pp.55 - 65
- Journal Title
- 대한한의학회지
- Volume
- 41
- Number
- 3
- Start Page
- 55
- End Page
- 65
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78169
- ISSN
- 1010-0695
- Abstract
- Objectives: This study aimed to evaluate the toxicity of CP pharmacopunture using bacterial reverse mutation test.
Methods: To determine the mutagenic potential of CP pharmacopunture, histidine requiring Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and tryptophan requiring Escherichia coli (WP2uvrA, pKM101) strains were used. The negative (normal saline solution) and positive (Sodium azide, 2-Nitrofluorene, 2-Aminoanthracene, 9-Aminoacridine, and 4-Nitroquinoline N-oxide) control groups were used. To determine the dose levels of the main study, a dose range-finding study was conducted.
Results: As a results of the dose range-finding study, the growth inhibition by CP pharmacopunture was not evident at any dose levels in the absence and presence of metabolic activation. As a results of the main study, the mean number of revertant colonies was less than twice when compared to the negative control values at all dose levels of the CP pharmacopuncture in the presence and absence of metabolic activation, showing no dose-related increase. In the positive control group, the number of revertant colonies was markedly increased by more than twice when compared to the negative control group.
Conclusion: According to the results of this study, CP pharmacopunture did not show any signs of mutagenic potential.
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