Highly branched α-limit dextrins attenuate the glycemic response and stimulate the secretion of satiety hormone peptide YY
- Authors
- Shim Y.-E.; Lee E.-S.; Hong M.-G.; Kim D.K.; Lee B.-H.
- Issue Date
- Nov-2020
- Publisher
- Elsevier B.V.
- Keywords
- Attenuated glycemic response; Branched α-limit dextrins; Glucose generation; Satiety hormone peptide YY; Slow digestibility; α-Amylase
- Citation
- Food Hydrocolloids, v.108
- Journal Title
- Food Hydrocolloids
- Volume
- 108
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78217
- DOI
- 10.1016/j.foodhyd.2020.106057
- ISSN
- 0268-005X
- Abstract
- Starch molecules are hydrolyzed to linear malto-oligosaccharides and branched α-limit dextrins (α-LDx) by salivary and pancreatic α-amylases in the gastrointestinal tract. In this study, we investigated the physiological responses to chromatographically purified branched α-LDx, which are slowly hydrolyzed owing to their high α-1,6 linkage ratios. Our results demonstrate that the digestion of branched α-LDx by mammalian α-glucosidases is slower than that of malto-oligosaccharides in vitro. In vivo experiments using mice showed that the glucose spike at the initial stage of α-LDx hydrolysis was significantly (p < 0.05) attenuated owing to an extended glycemic response. Branched α-LDx stimulated the secretion of peptide YY, which controls the satiety level and rate of gastric emptying by regulating the hypothalamus activity. In conclusion, the slow digestibility of branched α-LDx decelerated glucogenesis in vitro and in vivo; this phenomenon may result in beneficial physiological effects for regulate type 2 diabetes, obesity, and related chronic diseases by controlling post-prandial glucose homeostasis. © 2020 Elsevier Ltd
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