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Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity
- Authors
- Thuy N.T.K.; Phuong P.T.; Mai N.T.; Hien T.T.T.; Cuc N.T.; Tai B.H.; Kiem P.V.; Minh C.V.; Kang, Ki Sung; Kim, Seung Huyn; Nhiem N.X.
- Issue Date
- Jun-2020
- Publisher
- ELSEVIER
- Keywords
- Apocynaceae; Dregea volubilis; Pregnane glycoside; Volubiloside; α-Glucosidase
- Citation
- Phytochemistry Letters, v.37, pp.90 - 94
- Journal Title
- Phytochemistry Letters
- Volume
- 37
- Start Page
- 90
- End Page
- 94
- ISSN
- 1874-3900
- Abstract
- Three new pregnane glycosides namely volubilosides D-F (1–3) along with three known, dregeoside Da1 (4), volubiloside A (5), and drevoluoside N (6) were isolated from the methanol extract of the leaves of Dregea volubilis using combined chromatographic methods. Their structures were elucidated by 1D-, 2D-NMR, and HR-ESI-MS spectra and comparing with those reported in the literature. Compounds 5 and 6 showed the most significant α-glucosidase inhibitory activity at the concentration of 40 μM with inhibition of 51.3 ± 3.2% and 50.4 ± 3.1%, respectively, compared to acarbose (59.8 ± 1.6%). © 2020 Phytochemical Society of Europe
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Related Researcher
- Kang, Ki Sung
- College of Korean Medicine (Premedical course of Oriental Medicine)