Advances in amyloid beta oligomer detection applications in Alzheimer's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jamerlan, Angelo | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Hulme, John | - |
dc.date.available | 2020-09-23T02:35:24Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0165-9936 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78276 | - |
dc.description.abstract | Changes in amyloid-beta-oligomer (AβΟ) peptides levels are considered one of the major neuropathologic biomarkers for Alzheimer's Disease (AD). AβΟ levels can be detected using a variety of techniques such as neuroimaging, single molecule detection, immunoassays, and polymerase chain reaction (PCR). However, such techniques are usually reserved for individuals with mild cognitive decline or symptoms of late onset AD often to the exclusion of those with subjective memory complaints and patients in the early presymptomatic stages of AD. Recently, many scientists have sought to address this issue by integrating these techniques onto a single device or inexpensive platform permitting routine measurements of AβΟ concentrations outside the clinic. In this review, we examine the different types of clinical AβΟ commercial assays and established analytical techniques currently employed in the diagnosis of AD as well as integrated optical and electrochemical sensing devices currently under development. © 2020 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | TRAC-TRENDS IN ANALYTICAL CHEMISTRY | - |
dc.title | Advances in amyloid beta oligomer detection applications in Alzheimer's disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000567352000002 | - |
dc.identifier.doi | 10.1016/j.trac.2020.115919 | - |
dc.identifier.bibliographicCitation | TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v.129 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85086994216 | - |
dc.citation.title | TRAC-TRENDS IN ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 129 | - |
dc.contributor.affiliatedAuthor | Jamerlan, Angelo | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.contributor.affiliatedAuthor | Hulme, John | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Alzheimers disease | - |
dc.subject.keywordAuthor | Amyloid-beta-oligomer | - |
dc.subject.keywordAuthor | Device | - |
dc.subject.keywordAuthor | Electrochemical | - |
dc.subject.keywordAuthor | Inexpensive | - |
dc.subject.keywordAuthor | Neuroimaging | - |
dc.subject.keywordAuthor | Optical | - |
dc.subject.keywordAuthor | Presymptomatic | - |
dc.subject.keywordPlus | Diagnosis | - |
dc.subject.keywordPlus | Glycoproteins | - |
dc.subject.keywordPlus | Neurodegenerative diseases | - |
dc.subject.keywordPlus | Neuroimaging | - |
dc.subject.keywordPlus | Oligomers | - |
dc.subject.keywordPlus | Proteins | - |
dc.subject.keywordPlus | Alzheimer&apos | - |
dc.subject.keywordPlus | s disease | - |
dc.subject.keywordPlus | Amyloid betas | - |
dc.subject.keywordPlus | Cognitive decline | - |
dc.subject.keywordPlus | Commercial assays | - |
dc.subject.keywordPlus | Electrochemical sensing devices | - |
dc.subject.keywordPlus | Measurements of | - |
dc.subject.keywordPlus | Single-molecule detection | - |
dc.subject.keywordPlus | Polymerase chain reaction | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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