Decreased plasma α-synuclein in idiopathic Parkinson’s disease patients after adjusting hemolysis factor
DC Field | Value | Language |
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dc.contributor.author | Shim, K.H. | - |
dc.contributor.author | Kim, S.C. | - |
dc.contributor.author | Youn, Y.C. | - |
dc.contributor.author | Sung, Y.-H. | - |
dc.contributor.author | An, S.S.A. | - |
dc.date.available | 2020-10-20T00:58:20Z | - |
dc.date.created | 2020-09-24 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78298 | - |
dc.description.abstract | Background: Lewy bodies are pathological hallmarks for the diagnosis of Parkinson’s disease, where the core components are composed of aggregated forms of α-synuclein (α-syn). Although α-syn has been investigated as a potential biomarker for PD, its usage has been limited and still remains controversial. Objective: An accurate enzyme-linked immunosorbent assay (ELISA) was developed for the detection of α-syn in plasma. The hemolysis score was calculated to eliminate the additive α-syn levels from RBCs. Human plasma samples were collected in heparinized blood tubes from idiopathic Parkinson disease (IPD) and healthy control (HC). Result: Hemolysis score had a strong correlation with the level of plasma α-syn. From the limited set of samples in this preliminary study, decreased α-syn concentrations were observed in patients with IPD in comparison to HC after adjusting for hemolysis factor. Similar results with a commercial ELISA kit were found for measuring α-syn from the same set of samples with lower correlation and the reduced accuracy of diagnosis than the current study. Conclusion: The adjustments for the hemolysis factor would be indispensable, supporting plasma α-syn as a potential surrogate biomarker for distinguishing IPD from HC. © 2020, The Korean Society of Toxicogenomics and Toxicoproteomics 2020. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | Molecular and Cellular Toxicology | - |
dc.title | Decreased plasma α-synuclein in idiopathic Parkinson’s disease patients after adjusting hemolysis factor | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000569534700001 | - |
dc.identifier.doi | 10.1007/s13273-020-00104-7 | - |
dc.identifier.bibliographicCitation | Molecular and Cellular Toxicology, v.16, no.4, pp.477 - 484 | - |
dc.identifier.kciid | ART002631296 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85090929477 | - |
dc.citation.endPage | 484 | - |
dc.citation.startPage | 477 | - |
dc.citation.title | Molecular and Cellular Toxicology | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Kim, S.C. | - |
dc.contributor.affiliatedAuthor | Sung, Y.-H. | - |
dc.contributor.affiliatedAuthor | An, S.S.A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hemolysis | - |
dc.subject.keywordAuthor | Parkinson’s disease | - |
dc.subject.keywordAuthor | α-Synuclein | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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