Ishige okamurae reduces blood glucose levels in high-fat diet mice and improves glucose metabolism in the skeletal muscle and pancreasIshige okamurae reduces blood glucose levels in high-fat diet mice and improves glucose metabolism in the skeletal muscle and pancreas
- Other Titles
- Ishige okamurae reduces blood glucose levels in high-fat diet mice and improves glucose metabolism in the skeletal muscle and pancreas
- Authors
- 양혜원; 손명주; Junwon Choi; 오세연; 전유진; 변경희; 유보미
- Issue Date
- Sep-2020
- Publisher
- 한국수산과학회
- Keywords
- Ishige okamurae; Diabetes; High-fat diet mice; Skeletal muscle; Pancreas
- Citation
- Fisheries and Aquatic Sciences, v.23, no.3, pp.1 - 9
- Journal Title
- Fisheries and Aquatic Sciences
- Volume
- 23
- Number
- 3
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78369
- DOI
- 10.1186/s41240-020-00168-5
- ISSN
- 2234-1749
- Abstract
- Brown alga (Ishige okamurae; IO) dietary supplements have been reported to possess anti-diabetic properties.
However, the effects of IO supplements have not been evaluated on glucose metabolism in the pancreas and skeletal muscle. C57BL/6 N male mice (age, 7 weeks) were arranged in five groups: a chow diet with 0.9% saline (NFD/saline group), high-fat diet (HFD) with 0.9% saline (HFD/saline group). high-fat diet with 25 mg/kg IO extract (HFD/25/IOE). high-fat diet with 50 mg/kg IO extract (HFD/50/IOE), and high-fat diet with 75 mg/kg IO extract (HFD/ 75/IOE). After 4 weeks, the plasma, pancreas, and skeletal muscle samples were collected for biochemical analyses.
IOE significantly ameliorated glucose tolerance impairment and fasting and 2 h blood glucose level in HFD mice.
IOE also stimulated the protein expressions of the glucose transporters (GLUTs) including GLUT2 and GLUT4 and those of their related transcription factors in the pancreases and skeletal muscles of HFD mice, enhanced glucose metabolism, and regulated blood glucose level. Our results suggest Ishige okamurae extract may reduce blood glucose levels by improving glucose metabolism in the pancreas and skeletal muscle in HFD-induced diabetes.
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