Neuroprotective effects of vomifoliol, isolated from Tarenna obtusifolia Merr. (Rubiaceae), against amyloid-beta 1-42-treated neuroblastoma SH-SY5Y cells
DC Field | Value | Language |
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dc.contributor.author | Tan, M.A. | - |
dc.contributor.author | Gonzalez, S.J.B. | - |
dc.contributor.author | Alejandro, G.J.D. | - |
dc.contributor.author | An, S.S.A. | - |
dc.date.available | 2020-10-20T01:02:23Z | - |
dc.date.created | 2020-09-21 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2190-572X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78397 | - |
dc.description.abstract | Phytochemical investigation on the leaves of Tarenna obtusifolia Merr. (Rubiaceae) led to the isolation and identification of vomifoliol (1), p-coumaric acid (2), and stigmasterol (3) based on spectroscopic analyses and comparison with the literature data. Compound 1 moderately inhibited the aggregation of amyloid-beta (Aβ1–42) using the ThT assay (55.71% at 50 μM) and exhibited neuroprotective effects against amyloid-beta (Aβ1–42)-induced cytotoxicity in neuroblastoma SH-SY5Y cells at 20 μM concentration. This is the first phytochemical study on T. obtusifolia and the first report on the Aβ aggregation activity and neuroprotective potential of vomifoliol (1). © 2020, King Abdulaziz City for Science and Technology. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | 3 Biotech | - |
dc.title | Neuroprotective effects of vomifoliol, isolated from Tarenna obtusifolia Merr. (Rubiaceae), against amyloid-beta 1-42-treated neuroblastoma SH-SY5Y cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000571784100003 | - |
dc.identifier.doi | 10.1007/s13205-020-02421-z | - |
dc.identifier.bibliographicCitation | 3 Biotech, v.10, no.10 | - |
dc.identifier.scopusid | 2-s2.0-85090789385 | - |
dc.citation.title | 3 Biotech | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Tan, M.A. | - |
dc.contributor.affiliatedAuthor | An, S.S.A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Amyloid-beta | - |
dc.subject.keywordAuthor | Neuroprotective effects | - |
dc.subject.keywordAuthor | Rubiaceae | - |
dc.subject.keywordAuthor | Tarenna | - |
dc.subject.keywordAuthor | Vomifoliol | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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