Wasabisides A-E, Lignan Glycosides from the Roots of Wasabia japonica
- Authors
- Kim, Chung Sub; Subedi, Lalita; Kwon, Oh Wook; Park, Hyun Bong; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Oct-2016
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.79, no.10, pp.2652 - 2657
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 79
- Number
- 10
- Start Page
- 2652
- End Page
- 2657
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7860
- DOI
- 10.1021/acs.jnatprod.6b00582
- ISSN
- 0163-3864
- Abstract
- Five new lignan glycosides, wasabisides A-E (1-5), and four known phenolic compounds (6-9), were isolated from the roots of Wasabia japonica. The chemical structures of the new compounds (1-5) were determined through spectroscopic analysis and chemical methods. All isolated compounds (1-9) were evaluated for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells, and for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and BT549).
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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