Multimodal mesoporous silica nanocarriers for dual stimuli-responsive drug release and excellent photothermal ablation of cancer cells
DC Field | Value | Language |
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dc.contributor.author | Tran, V.A. | - |
dc.contributor.author | Vo, V.G. | - |
dc.contributor.author | Shim, K. | - |
dc.contributor.author | Lee, S.-W. | - |
dc.contributor.author | An, S.S.A. | - |
dc.date.available | 2020-10-28T05:40:22Z | - |
dc.date.created | 2020-10-26 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78746 | - |
dc.description.abstract | Background: Core-shell types of mesoporous silica nanoparticles (MSNs) with multimodal functionalities were developed for bio-imaging, controlled drug release associated with external pH, and near-infrared radiation (NIR) stimuli, and targeted and effective chemo-photothermal therapeutics. Materials and Methods: We synthesized and developed a core-shell type of mesoporous silica nanocarriers for fluorescent imaging, stimuli-responsive drug release, magnetic separation, antibody targeting, and chemo-photothermal therapeutics. Also, the biocompatibility, cellular uptake, cytotoxicity, and photothermal therapy on these FS3-based nanocarriers were systematically investigated. Results: Magnetic mesoporous silica nanoparticles was prepared by coating a Fe3O4 core with a mesoporous silica shell, followed by grafting with fluorescent conjugates, so-called FS3. The resulting FM3 was preloaded with therapeutic cisplatin and coated with polydopamine layer, so-called FS3P/C. Eventually, graphene oxide-wrapped FS3P/C (FS3P-G/C) exhibited high sensitivity in the dual stimuli (pH, NIR)-responsive controlled release behavior. On the other hand, Au NPs-coated FS3P/C (FS3P-A/C) exhibited more stable release behavior, irrespective of pH changes, and exhibited much more enhanced release rate under the same NIR irradiation. Notably, FS3P-A/C showed strong NIR absorption, enabling photothermal destruction of HeLa cells by its chemo-photothermal therapeutic effects under NIR irradiation (808 nm, 1.5 W/cm2). The selective uptake of FS3-based nanocarriers was confirmed in cancer cell lines including HeLa (American Type Culture Collection-ATCC) and SHSY5Y (ATCC 2266) by the images obtained from confocal laser scanning microscopy, flow cytometry, and transmission electron microscopy instruments. Cisplatin-free FS3-based nanocarriers revealed good cellular uptake and low cytotoxicity against cancerous HeLa and SH-SY5Y cells, but showed no obvious toxicity to normal HEK293 (ATCC 1573) cell. Conclusion: Along with the facile synthesis of FS3-based nanocarriers, the integration of all these strategies into one single unit will be a prospective candidate for biomedical applications, especially in chemo-photothermal therapeutics, targeted delivery, and stimuli-responsive controlled drug release against multiple cancer cell types. © 2020, Dove Medical Press Ltd.. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Dove Medical Press Ltd | - |
dc.relation.isPartOf | International Journal of Nanomedicine | - |
dc.title | Multimodal mesoporous silica nanocarriers for dual stimuli-responsive drug release and excellent photothermal ablation of cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000577557400005 | - |
dc.identifier.doi | 10.2147/IJN.S254344 | - |
dc.identifier.bibliographicCitation | International Journal of Nanomedicine, v.15, pp.7667 - 7685 | - |
dc.identifier.scopusid | 2-s2.0-85092793390 | - |
dc.citation.endPage | 7685 | - |
dc.citation.startPage | 7667 | - |
dc.citation.title | International Journal of Nanomedicine | - |
dc.citation.volume | 15 | - |
dc.contributor.affiliatedAuthor | Tran, V.A. | - |
dc.contributor.affiliatedAuthor | Vo, V.G. | - |
dc.contributor.affiliatedAuthor | Lee, S.-W. | - |
dc.contributor.affiliatedAuthor | An, S.S.A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Au NPs | - |
dc.subject.keywordAuthor | Cancerous cells | - |
dc.subject.keywordAuthor | Chemo-photothermal therapy | - |
dc.subject.keywordAuthor | Mesoporous silica NPs | - |
dc.subject.keywordAuthor | Stimuli-responsive drug release | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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