Evaluation of anti-colitis effect of km1608 and biodistribution of dehydrocostus lactone in mice using bioimaging analysis
- Authors
- Lee, S.; Kim, S.-B.; Lee, J.; Park, J.; Choi, S.; Hwang, G.S.; Choi, H.-S.; Kang, K.S.
- Issue Date
- Sep-2020
- Publisher
- MDPI AG
- Keywords
- Bioimaging; Inflammatory bowel disease; KM1608
- Citation
- Plants, v.9, no.9, pp.1 - 12
- Journal Title
- Plants
- Volume
- 9
- Number
- 9
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78888
- DOI
- 10.3390/plants9091175
- ISSN
- 2223-7747
- Abstract
- Inflammatory bowel disease (IBD) is a chronic relapsing disorder modulated by numerous factors. Recent failures of drugs targeting single factors suggest that multitargeting drugs could be useful for the treatment of IBD. Natural medicines may be an alternative option for the treatment of IBD, owing to the complex nature of the disease. However, most natural medicines have poor in vitro and in vivo translational potential because of inadequate pharmacokinetic study. KM1608, a mixture of the medicinal plants Aucklandia lappa, Terminalia chebula, and Zingiber officinale, was examined for its anti-colitis effects and biodistribution using bioimaging. Dehydrocostus lactone, as a marker compound, was analyzed to assess the biodistribution of KM1608. KM1608 significantly attenuated the disease activity of dextran sodium sulfate-induced colitis in mice and suppressed inflammatory mediators such as myeloperoxidase, proinflammatory cytokines (TNF-α and IL-6), and the Th2-type cytokine IL-4 in the colon. Optical fluorescence imaging revealed that KM1608 was distributed in the intestinal area as a target organ. Collectively, our findings suggest that KM1608 is a potential therapeutic formulation for IBD. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의예과 > 1. Journal Articles
- 한의과대학 > 한의학과 > 1. Journal Articles
- 바이오나노대학 > 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78888)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.