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신생아 약동학과 약물요법Pharmacokinetics and drug therapy in neonates

Other Titles
Pharmacokinetics and drug therapy in neonates
Authors
조혜정
Issue Date
Jun-2017
Publisher
대한소아응급의학회
Keywords
.; Bronchiolitis; Drug Administration Routes; Drug Therapy; Infants; Newborn; Pharmacokinetics
Citation
대한소아응급의학회지, v.4, no.1, pp.5 - 11
Journal Title
대한소아응급의학회지
Volume
4
Number
1
Start Page
5
End Page
11
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78976
DOI
10.22470/pemj.2017.00059
ISSN
2383-4897
Abstract
Neonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption, distribution, metabolism, and elimination. This feature should be considered in determining the dose and regimen of drug therapy in neonates. However, the research on the safety and efficacy of specific drugs is limited due to ethical and technical issues. This review article focuses on the neonatal pharmacokinetics and the rationales of drug therapy in neonates based on findings of previous studies and empirical evidence.
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