Attenuating effects of pyrogallol-phloroglucinol-6,6-bieckol on vascular smooth muscle cell phenotype changes to osteoblastic cells and vascular calcification induced by high fat diet
DC Field | Value | Language |
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dc.contributor.author | Son, M. | - |
dc.contributor.author | Oh, S. | - |
dc.contributor.author | Jang, J.T. | - |
dc.contributor.author | Park, C.-H. | - |
dc.contributor.author | Son, K.H. | - |
dc.contributor.author | Byun, K. | - |
dc.date.available | 2020-11-26T00:40:32Z | - |
dc.date.created | 2020-09-18 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79079 | - |
dc.description.abstract | Advanced glycation end products/receptor for AGEs (AGEs/RAGEs) or Toll like receptor 4 (TLR4) induce vascular smooth muscle cell (VSMC) phenotype changes in osteoblast-like cells and vascular calcification. We analyzed the effect of Ecklonia cava extract (ECE) or pyrogallol-phloroglucinol-6,6-bieckol (PPB) on VSMC phenotype changes and vascular calcification prompted by a high-fat diet (HFD). HFD unregulated RAGE, TLR4, transforming growth factor beta (TGFβ), bone morphogenetic protein 2 (BMP2), protein kinase C (PKC), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signals in the aorta of mice. ECE and PPB restored the increase of those signal pathways. AGE-or palmitate-treated VSMC indicated similar changes with the animal. HFD increased osteoblast-like VSMC, which was evaluated by measuring core-binding factor alpha-1 (CBFα-1) and osteocalcin expression and alkaline phosphatase (ALP) activity in the aorta. ECE and PPB reduced vascular calcification, which was analyzed by the calcium deposition ratio, and Alizarin red S stain was increased by HFD. PPB and ECE reduced systolic, diastolic, and mean blood pressure, which increased by HFD. PPB and ECE reduced the phenotype changes of VSMC to osteoblast-like cells and vascular calcification and therefore lowered the blood pressure. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Nutrients | - |
dc.title | Attenuating effects of pyrogallol-phloroglucinol-6,6-bieckol on vascular smooth muscle cell phenotype changes to osteoblastic cells and vascular calcification induced by high fat diet | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000580088700001 | - |
dc.identifier.doi | 10.3390/nu12092777 | - |
dc.identifier.bibliographicCitation | Nutrients, v.12, no.9, pp.1 - 13 | - |
dc.identifier.scopusid | 2-s2.0-85090580290 | - |
dc.citation.endPage | 13 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Nutrients | - |
dc.citation.volume | 12 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Son, M. | - |
dc.contributor.affiliatedAuthor | Oh, S. | - |
dc.contributor.affiliatedAuthor | Park, C.-H. | - |
dc.contributor.affiliatedAuthor | Son, K.H. | - |
dc.contributor.affiliatedAuthor | Byun, K. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Ecklonia cava extract | - |
dc.subject.keywordAuthor | Pyrogallol-phloroglucinol-6,6-bieckol | - |
dc.subject.keywordAuthor | Receptor of AGEs | - |
dc.subject.keywordAuthor | Toll-like receptor 4 | - |
dc.subject.keywordAuthor | Vascular calcification | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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