Sex Difference in the Association Between Metabolic Syndrome and Obstructive Coronary Artery Disease: Analysis of Data from the KoRean wOmen'S chest pain rEgistry (KoROSE)
- Authors
- Lee, Hak Seung; Kim, Hack-Lyoung; Kim, Myung-A; Oh, Sohee; Kim, Mina; Park, Sang Min; Yoon, Hyun Ju; Byun, Young Sup; Park, Seong Mi; Shin, Mi Seung; Hong, Kyung-Soon; Shim, Wan-Joo
- Issue Date
- Dec-2020
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- chest pain; coronary artery disease; sex difference; metabolic syndrome
- Citation
- JOURNAL OF WOMENS HEALTH, v.29, no.12, pp.1500 - 1506
- Journal Title
- JOURNAL OF WOMENS HEALTH
- Volume
- 29
- Number
- 12
- Start Page
- 1500
- End Page
- 1506
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79513
- DOI
- 10.1089/jwh.2020.8488
- ISSN
- 1540-9996
- Abstract
- Background: The sex-related impact of metabolic syndrome (MetS) on obstructive coronary artery disease (OCAD) has not been well evaluated. Methods: A total of 1156 patients (62 years and 58% women) with chest pain undergoing invasive coronary angiography (CAG) were recruited from the database of the nation-wide chest pain registry. MetS was defined according to the criteria of the International Diabetes Federation. OCAD was defined as >= 50% stenosis of the left main coronary artery and/or >= 70% stenosis of any other coronary arteries. Results: Women were older than men (65 vs. 59 years, p < 0.001). OCAD (32.0% vs. 30.9%) and MetS (27.8% vs. 27.9%) prevalence rates were similar in both sexes (p > 0.05). The presence of MetS was associated with higher prevalence of OCAD in women (24.5% vs. 47.3%, p < 0.001), but not in men (31.0% vs. 34.3%, p = 0.487). The linear association between the number of components meeting MetS criteria and OCAD prevalence was significant in both sexes (p < 0.001 for each), but it was stronger in women than in men (Chi-square value: 81.9 vs. 14.8, p < 0.001). In a multivariable model, the presence of MetS was independently associated with OCAD in women even after controlling for potential confounders (odds ratio, 1.92; 95% confidence interval, 1.31-2.81; p = 0.001). Conclusions: In patients with chest pain undergoing invasive CAG, the association between the number of components meeting MetS criteria and OCAD prevalence was stronger in women than in men.
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