Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice
- Authors
- Titlow, William B.; Waqas, Muhammad; Lee, Jihyun; Cho, Jae Youl; Lee, Sang Yeol; Kim, Dae-Hwan; Ryou, Chongsuk
- Issue Date
- Sep-2016
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Prion; PrPSc; animal model; spleen; brain; polylysine
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.26, no.9, pp.1657 - 1660
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 26
- Number
- 9
- Start Page
- 1657
- End Page
- 1660
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7961
- DOI
- 10.4014/jmb.1601.01057
- ISSN
- 1017-7825
- Abstract
- Prion diseases are incurable neurodegenerative disorders. Our previous study demonstrated that polylysine was effective in prolonging the incubation period in a rodent model and in alleviating the scrapie prion protein (PrPSc) burden in the brain at the terminal stage of the disease. Here, we report that intraperitoneal administration of polylysine suppresses the accumulation of prions in the spleen during the early stages of the disease. This study supports the congruence of PrPSc inhibition by polylysine in both the spleen and brain.
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